Final Scientific Programme

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Day 1 – Thursday, April 29

Arrival of conferees, registration, get-together party

Session 1
Welcoming and Opening Remarks
Chairman: Jan Svoboda

04:30 - 05:00 pm Jan Svoboda, Institute of Molecular Genetics, Prague
Background and perspectives
05:00 - 06:00 pm David Baltimore, California Institute of Technology, Pasadena
Keynote lecture
06:00 pm Welcome reception

Day 2 – Friday, April 30

Session 2
Action at the Cell Surface
Chairmen: John A.T. Young, Benjamin K. Chen

08:30 - 09:00 am John A.T. Young, Salk Institute, La Jolla
Cellular factor involvement in retroviral replication
09:00 - 09:30 am Benjamin K. Chen, Mount Sinai School of Medicine, New York
Spread of HIV through T cell virological synapses
09:30 - 09:45 am Paul Jolicoeur, Clinical Research Institute of Montreal
Pathogenesis of HIV-1 Nef in thymocytes
09:45 - 10:00 am Michaela Rumlová, Institute of Organic Chemistry and Biochemistry, Prague
Analysis of N-terminus of NC protein of M-PMV: its role in the particle assembly
10:00 - 10:30 am Coffee break

Session 3
Identification of Essential Host Cell Factors
Chairmen: Stephen P. Goff, Alan N. Engelmam

10:30 - 11:00 am Stephen P. Goff, Columbia University, New York
HIV-1 Interactions with host proteins
11:00 - 11:30 am Alan N. Engelmam, Dana-Farber Cancer Institute, Boston
HIV-1 preintegration complex function and host cell factors
11:30 - 11:45 am Peter Cherepanov, Imperial College London
Structural basis for retroviral pre-integration complex assembly and strand transfer inhibitor action
11:45 - 12:00 am C. Martin Stoltzfus, University of Iowa, Iowa City
Defective HIV-1 Gag localization and assembly under conditions of excessive viral RNA splicing
12:00 - 02:00 pm Lunch and poster viewing

Session 4
Insights from Studies of Intracellular Trafficking
Chairmen: Thomas J. Hope, Paul Bieniasz

02:00 - 02:30 pm Thomas J. Hope, Northwestern University, Chicago
Cell biology of intracellular HIV
02:30 - 03:00 pm Paul Bieniasz, Aaron Diamond AIDS Research Center, Rockefeller University, New York
Visualizing HIV-1 virion genesis
03:00 - 03:15 pm Eric Hunter, Emory University School of Medicine, Atlanta
The role of microtubule and actin cytoskeletal networks in the intracellular transport of the Mason-Pfizer monkey virus capsids
03:15 - 03:30 pm Paul Spearman, Emory University School of Medicine, Atlanta
Tetherin endocytosis and HIV replication in human macrophages
03:30 - 04:00 pm Coffee break

Session 5
Retroviruses and Retroelements as Agents of Genome Rearrangement
Chairmen: Suzanne B. Sandmeyer, Haig H. Kazazian

04:00 - 04:30 pm Suzanne B. Sandmeyer, University of California Irvine
Adaptive targeting by retrotransposons as a force for genomic remodeling
04:30 - 05:00 pm Haig H. Kazazian, Jr, University of Pennsylvania, Philadelphia
High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
05:00 - 05:15 pm René Daniel, Thomas Jefferson University, Philadelphia
HIV-1 integration site preferences in pluripotent stem cells
05:15 - 07:00 pm Poster session
07:00 - 09:30 pm Cocktail party for invited speakers and guests, Villa Lanna

Day 3 – Saturday, May 1

Session 6
Retrovirus Evolution
Chairmen: John Coffin, Paul M. Sharp

08:30 - 09:00 am John Coffin, Tufts University, Boston
Evolution of the Alpharetrovirus-receptor interaction
09:00 - 09:30 am Paul M. Sharp, University of Edinburgh
The evolution of HIV-1 and the origin of AIDS
09:30 - 09:45 am Naomi Rosenberg, Tufts University, Boston
v-onc gene containing retroviruses and target cell specificity: insights revealed by Abelson virus
09:45 - 10:00 am K. Hanke, Robert Koch Institute, Berlin
Staufen-1 interacts with the HERV-K Rec protein affecting viral RNA transport and assembly processes
10:00 - 10:30 am Coffee break

Session 7
Retroviral Vectors and Retrovirus Persistence
Chairmen: Stephen H. Hughes, Ashley T. Haase

10:30 - 11:00 am Stephen H. Hughes, National Cancer Institute, Frederick
Lens epithelium derived growth factor (LEDGF) fusion proteins that redirect HIV-1 DNA integration
11:00 - 11:30 am Ashley T. Haase, University of Minnesota, Minneapolis
Retrovirus and lentivirus persistence and reservoirs from visna virus to HIV-1
11:30 - 11:45 am Mikulas Popovic, Institute of Human Virology, Baltimore
Host cells for human retroviruses: lessons from infection of mammalian cells with avian sarcoma virus
11:45 - 02:00 pm Lunch and poster viewing

Session 8
Cellular Defenses
Chairmen: Michael Malim, Jonathan Stoye

02:00 - 02:30 pm Michael Malim, King´s College London
Cellular APOBEC3 proteins and HIV-1 Vif
02:30 - 03:00 pm Jonathan Stoye, National Institute for Medical Research, London
Capsid binding restriction factors
03:00 - 03:15 pm Jeremy Luban, University of Geneva
TRIM5 is a retroviral capsid-specific receptor that contributes to the antiviral state
03:15 - 03:30 pm M. Blissenbach, Ruhr University Bochum
Nuclear RNA export and packaging functions of HIV-1 Rev revisit
03:30 - 04:00 pm Coffee break

Session 9
Epigenetic Effects on Retroviral Gene Expression
Chairmen: Richard A. Katz, David M. Margolis

04:00 - 04:30 pm Richard A. Katz, Fox Chase Cancer Center, Philadelphia
Identification of host factors that initiate and maintain retroviral epigenetic silencing
04:30 - 05:00 pm David M. Margolis, University of Northern Carolina, Chapel Hill
Epigenetic regulation of the HIV promoter and approaches to persistent retroviral infection
05:00 - 05:15 pm Jiri Hejnar, Institute of Molecular Genetics, Prague
CpG methylation and transcriptional suppression of endogenous retroviruses and retroviral vectors
05:15 - 07:00 pm Poster session

Day 4 – Sunday, May 2

Session 10
Mechanisms of Disease
Chairmen: Peter K. Vogt, Robin A. Weiss

09:00 - 09:30 am Peter K. Vogt, Scripps Research Institute, La Jolla
Oncogenic mutations in PI3K: genetic and mechanistic considerations
09:30 - 10:00 am Robin A. Weiss, University College London
Transmissible cancer cells
10:00 - 10:15 am Karen Beemon, Johns Hopkins University, Baltimore
Avian leukosis virus oncogenesis involves integrations that activate oncogenes, microRNA-155, and TERT
10:15 - 10:45 am Coffee break

Session 11
Roles of Innate and Adapted Defenses in Infections by Retroviruses
Chairmen: Francis W. Ruscetti, Malcolm A. Martin

10:45 - 11:15 am Francis W. Ruscetti, National Institutes of Health, Bethesda
Cell-free HTLV-1-Infection of PLASMAcytoid AND mYELOID Dendritic cells IN VITRO: Pathogenic Considerations of in vivo infection of Dendritic Cells
11:15 - 11:45 am Malcolm A. Martin, National Institutes of Health, NIAID, Bethesda
HIV 1 acquisition: SIV and SHIV models of acute primate lentivirus infections in macaque monkeys
11:45 - 12:00 pm Kim J. Hasenkrug, National Institutes of Health, Rocky Mountain Laboratories, Hamilton
Adaptive immune responses to Friend virus infection in mice
12:00 - 12:15 pm Paula Pitha-Rowe, Johns Hopkins University, Baltimore
The role of innate antiviral response in HIV-1 infection
12:15 - 12:45 pm Sandwich lunch
12:45 - 05:00 pm Tour of Prague/Free Afternoon

Day 5 – Monday, May 3

Session 12
Anti-viral Strategies: Drugs and Vaccines
Chairman: Eric De Clercq

09:00 - 09:30 am Gary J. Nabel, National Institutes of Health, Bethesda
Rational Design of Envelope Surface Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
09:30 - 10:00 am Ronald C. Desroisiers, New England Primate Center, Southborough
Overcoming, or Circumventing, the Barriers to an AIDS Vaccine
10:00 - 10:30 am Coffee break

Session 13
Trends in Retroviral Therapy
Chairman: Ronald C. Desroisiers

10:30 - 11:00 am Erik De Clercq, Rega Institute for Medical Research, Leuven
Prospects of anti-HIV therapy
11:00 - 11:30 am Leonid Margolis, National Institutes of Health, NICHD, Bethesda
Exploiting coinfecting microbes to suppress HIV-1 infection
11:30 - 11:45 am Karin Moelling, University of Zurich
HIV suicide through viral RNase H
11:45 - 12:00 pm M. Katzman, Penn State College of Medicine, Hershey
A novel antiviral strategy of stimulating integrase's nonspecific nuclease activity to damage retroviral DNA
12:00 - 12:15 pm Duane Grandgenett, Saint Louis University
HIV-1 integrase: Concerted DNA integration and identification of a new major integrase-raltegravir-single DNA complex
12:15 - 02:00 pm Lunch and poster viewing

Session 14
Meeting Wind-up
Chairman: Anna M. Skalka

02:00 - 02:30 pm Françoise Barré-Sinoussi, Institute Pasteur, Paris
History and future of basic science in human retroviruses
02:30 - 03:00 pm Stephen P. Goff, Columbia University, New York
Summary observations
03:00 - 03:30 pm Anna M. Skalka, Fox Chase Cancer Center, Philadelphia
Closing remarks
05:00 - 09:00 pm Farewell dinner at the Grand Monastery Restaurant

Day 6 – Tuesday, May 4

Departure