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Czech Society for Biochemistry and Molecular Biology Federation of European Biochemical Societies

Detailed Symposia


1.1. Epigenetics: DNA Methylation and Far Beyond
Chairs: Adrian Bird, Boris Vyskot
Asymmetric cell division througfh epigenetic differentiation of sister chromatids and their selective segregation in mitosis
Amar S. Klar     
Genomic compartments based on CpG methylation
Adrian Bird   
Epigenomic programs and reprogramming in mammals
Joern E. Walter 
Epigenetic regulations of the X inactivation center by /cis/ and /trans/ activities
Pablo Navarro f

1.2. Evolution of Polyploid Genomesf
Chairs: Eric J. Richards, Aleš Kova?ík
Epigenetic variation and inheritance
Eric J. Richards 
Plant Chromosomes at Interphase - paired? cohesive? dynamic?
Ingo Schubert  
Genetics and epigenetics in autotetraploids
Ortrun Mittelsten-Scheid
Gene expression rewiring in interspecific hybrids and allopolyploids
Avraham A. Levy

1.3. Bioinformatics: from Comparisons to Functional Predictions
Chairs: Janet Thornton,  Fatima Cvr?ková
UniProtKB/Swiss-Prot: from sequences to functions
Amos Bairoch
Computational approaches to unveiling ancient genome duplications
Yves Van de Peer
Rama Ranganathan
-  title to be announced
Understanding the evolution of enzyme specificity through protein structures
Janet  Thornton 

W 02 Glycomic Technologies
Chairs: Anne Imberty, Jaroslav Ko?a
Novel glycan-binding receptors identified by genomic analysis
Kurt Drickamer 
NMR studies of free and protein-bound glycomimetics
Jesus Jimenéz-Barbero
Chemistry in living systems: new tools for probing the glycome
Carolyn R. Bertozzi
Mass spectrometric Stratergies for Glycomics and Glycoproteomics
Stuart Haslam
Protein engineering of carbohydrate binding proteins
Michaela Wimmerová

W 03 Emerging Proteomic Technologies
Chairs: Ruedi Aebersold, Marián Hajdúch
Proteomics as a genomic science.
Ruedi Aebersold
Chalenges in guantitative proteomics and posttranslational protein modifications
Mathias Mann
Glycoproteomics: Past, Present and Future
Howard R. Morris
Quantitative Analysis of Biochemical Activities and Disease using Protein Microarrays
Michael P. Snyder 
Pathway proteomics using protein arrays
Jan Van Oostrum
Mapping the human proteome using antibodies
Uhlen Mathias 


2.1 Protein Folding
Chairs: Michele Vendruscolo, Martin Lepsik
Cellular Signaling Regulated Protein Folding Pathways
Daniel Mueller 
Factors affecting protein association and fibrillation kinetics
Sara Linse 
Molecular Interactions (ET Protein-Protein Docking, using Docking Algorithms and Spectrosopy -NMR)
Jose J. Moura 
Towards quantitative predictions in cell biology using chemical properties of proteins
Michele Vendruscolo 
Changes of protein-folding pathways by circular permutation: overlapping nuclei promote global cooperativity
Mikael Oliveberg

2.2. Bioactive Peptides
Chairs: Charles Pineau, Petr Džubák
Comparative neuropeptidomics: the singular contribution of amphibians to the discovery of novel mammalian neuropeptides
Hubert Vaudry
Novel toxins from snake venoms
R. M. Kini
Evolution and development of peptides with special activities such as on ion-channels and receptors
Dietrich Mebs
Identification and characterization of novel anti-infectious peptides from the male genital tract
Charles  Pineau

2.3. Protein Engineering and Directed Evolution
Chairs: Daniel Tawfik, Ji?í Damborský
From random mutagenesis to focused directed evolution: examples for altered enantioselectivity and broadened substrate range
Uwe Bornscheurer
The makings of new enzymatic catalysts
Daniel Tawfik
Changing the catalytic function of enzymes: lessons from nature and protein engineering
Romas  Kazlauskas
Novel enzymes and designer microorganisms for industrial application: tapping functional sequence space from nature and beyond
Eck Jurgen

2.4. Proteolysis on and Within the Biological Membrane
Chairs: Matthew Freeman, Aleksi Šedo
Intramembrane proteolysis by rhomboid proteases
Matthew Freeman
Proteinase dysbalance in disease: The ACE and NEP gene families
Anthony J. Turner 
Intramembrane Proteolysis by GxGD Aspartyl Proteases
Christian Haass
Beyond proteolysis:  glutamate carboxypeptidase II as a neuropeptidase and prostate specific membrane antigen
Jan Konvalinka
Regulation of extracellular proteolysis by CUB-domain containing proteins
Jonathan Duke-Cohan


3.1. Biotransformation of Carcinogens
Chairs: D. H. Phillips, Pavel Anzenbacher
Effect of benzo[a]pyrene metabolism on cells, and vice versa
David H. Phillips
The Hepatic Cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism
Volker M. Arlt
Aristolochic acid an old drug is a human carcinogen
Heinz H. Schmeiser
Biotransformation of the plant alkaloid ellipticine dictates its genotoxic and pharmacological effects
Marie Stiborová
The fate of drugs conjugated to albumin: metabolism and effects on cellular targets
Eva Frei

3.2. Heme Biosynthesis, Utilization and Degradation
Chairs: C.S. Raman, Pavel Martásek
Metabolic basis of protoporphyrin accumulation in Erythropoïetic Protoporphyria: Ferrochelatase deficiency versus Ala Synthase 2 gain of function
Jean-Charles Deybach 
Lipid Mediator Signaling: Structural and Evolutionary Insights
C. S. Raman
Structural Insight of Heme Oxygenase Catalysis
Masao Ikeda-Saito
Macromolecular complexes involving heme containing enzymes
Ilme Schlichting

3.3. Turnover and Recognition of Carbohydrates
Chairs: Kurt Drickamer, Karel Bezouška
Interactions between bacterial lectines and host carbohydrates
Anne Imberty
Glycation and post-translational processing of human interferon-gamma expressed in Escherichia coli
Ivan Gueorguiev Ivanov 
Frontiers of Human Glycosylation Disorders
Hudson Freeze 
When PNGase -F fails to deglycosylate native N-glycoproteins - NMR and  modelling studies
Johannis P. Kamerling
Enzymes in the synthesi of new unique carbohydrate structures and their mimetics
Vladimír K?en

3.4. Cytochromes P450 and Xenobiochemistry
Chairs: Frederick P. Guengerich, Marie Stiborová
Searches for Cellular Functions of New (and Old) Cytochrome P450 Enzymes
Frederick P. Guengerich
Structural Genomics of the Human Drug Metabolizing Cytochrome P450 Monooxygenases
Eric Johnson
Cytochrome P450s as biomarkers for individualised drug therapy: genetic and epigenetic aspects
Magnus Ingelman-Sunderg
Changing substrate specicificity and activity of bacterial and mitochondrial P450 systems
Rita Bernhardt
Flexibility and plasticity of the structures of cytochromes P450 as a property determining their function
Pavel Anzenbacher


4.1. Cell Differentiation
Chairs: Pierre Jurdic, Jan Šmarda
Transcription factor AP-1(Fos/Jun) functions in Bone Cell differentiation
Erwin Wagner 
Epigenetic Regulation of Gene Expression by the Myb Oncoprotein and the E2F-RB Tumor Suppressor Complex
Joseph Lipsick
Origin and mode of function of bone resorbing osteoclasts
Pierre Jurdic
Understanding early haematopoietic development using human embryonic stem cell as a model
Majlinda Lako 

4.2. Biochemistry of Melanins and Melanosomes
Chairs: Patrick A. Riley, Jan Borovanský
Chemical and biophysical properties of eumelanins and phaeomelanins
Tadeusz Sarna 
The melanocortin 1 receptor and the regulation of the eumelanin/pheomelanin switch
José C. Garcia-Borrón
Physiological and pathological functions of melanosomes and their exploitation
Patrick A. Riley
Mutator phenotypes in pigment cells and mechanism(s) of their DNA damage
Stan Pavel
Role of b-catenin and associated proteins during normal and pathological development of melanocytes
Lionel Larue 

4.3. Extracellular Matrix and Cell Adhesion
Chairs: Bernhard Ganss, Radim ?erný
Extracellular matrix – integrin signalling mechanisms
Ellen Van Obberghen-Schilling
Extracellular Matrix and Tumor Stroma in Cancer Progression
Ruth Chiquet-Ehrismann
Stem Cells for Bone Tissue Regeneration
Michael  Wendel
Extracellular Matrix in Bone and Cartilage Pathologies
Taina Pihlajaniemi
Extracellular matrix in tooth enamel formation
Bernhard Ganss

4.4. The Cell Nucleus: Structure, Function and Dynamics
Chairs: Willian Earnshaw, Ivan Raška
The mammalian genome: Its duplication, organization and mobility
Cristina  Cardoso
Probing the epigenetic landscape of the human kinetochore
William Earnshaw 
Lamin complexes regulate tissue progenitor cells
Ronald Foisner
Genom Integrity: Mechanisms, nuclear dynamics, and relevance to cancer 
Jiri Bartek
Keeping track of multiple forms of actin in- and outside the nucleus
Ueli Aebi 

4.5. Function and Dysfunction of Mitochondria
Chairs: Jan Smeitink , Ji?í Zeman
Neuronal survival and spare respiratory capacity
David G. Nicholls
Complex I of the respiratory chain, from physiological regulation to pathological hereditary dysfunctions
Sergio Papa
Human Complex I: From Gene Cloning Towards Remedy
Jan Smeitink  
Vladimir Skulachev
New aspects of  nuclear encoded mitochondrial encephalopathies
Valeria Tiranti
Respiratory active mitochondrial supercomplexes
Jose Antonio Enriquez

4.6. RNA Turnover and Quality Control
Chairs: Elisa Izaurralde, Sandra Wolin
Mechanisms of Nonsense Mediated Decay
Elisa Izaurralde
RNA degradation in the yeast nucleus
David Tollervey 
Molecular mechanisms of RNA degradation
Elena Conti
The role of Ro and Y RNAs in noncoding RNA biogenesis and decay
Sandra Wolin
Olga A. Dontsova
– title to be announced

4.7. Nervous System Stem Cells
Chairs: Pasco Rakic, Karel Smetana
Adult neurogenesis, neurodegenerative disorders, and aging
Gerd Kempermann
Specification and integration of cerebellar GABAergic neurons
Ferdinando Rossi  
Neurobiological consequences of complete genetic ablation of adult brain neurogenesis
Leszek Kaczmarek 
Stem cells and treatment of brain and spinal cord Injury
Eva Sykova 

5.1. Cytoskeleton Dynamics
Chairs: Gregg Gundersen, Pavel Dráber
Regulation of microtubules and cell polarity by RhoGTPases in migrating cells
Gregg Gundersen
Systems approaches to cell division
Anthony A. Hyman
Links, switches and signalling networks of the integrin adhesome
Benjamin Geiger 
Pushing and pausing with actin during cell motility
Victor Small 

5.2. Reactive Oxygen Species in Cell Signalling
Chairs: Stanislav Štípek, Nesrin Kartal-Ozer
Gas sensing by potassium channels
Paul J.  Kemp 
Oxygen and Reactive Oxygen Species as Signals for Wound Repair
Chandan K. Sen 
Thiol redox signaling and the control of thiol oxidation by the thioredoxin and GSH pathways
Michel B. Toledano 
Nox family of NADPH oxidases: sources of reactive oxygen
Miklos Geiszt
Hypercholesterolemia-induced oxidative stress related chances in the brain of rabbits
Nesrin Kartal Ozer

5.3. Gaseous Signaling
Chairs: Salvador Moncada, Libor Vítek
Designer Nitric Oxide Synthases for Understanding the Production of Gaseous Signals
Bettie Sue Masters
Nitric oxide-carbon monoxide interaction and oxidative stress in obesity and diabete
Nader G. Abraham
Carbon monoxide: therapeutic properties from a poisonous gas
Roberto Motterlini
Mitochondria, nitric oxide and cell bioenergetics
Salvador Moncada
Endothelial cels - New terrirory for HO-1 biochemistry
Alicja Józkowicz 

5.4. Signalling in Plants
Chairs: Thomas Schmulling, Olga Valentová
Cytokinin signal perception and transduction
Thomas Schmülling
Plant phospholipases and phosphatidic acid-mediated signaling in stress responses
Xuemin (Sam)  Wang
Regulation of plant epidermal cell patterning by extra- cellular peptide mediators
Tatsuo Kakimoto
Regulation of cellular polarity 
Shaul Yalovsky
Cellular mechanism of polar auxin transport
Eva Zažímalová 

5.5. Small GTPases in Cell Function and Disease
Chairs: Anne J. Ridley, Keith Burridge
Spatio-temporal control of small G protein function during phagocytosis
Emmanuelle Caron
The immediate-early gene product RhoB - limiting the proliferation of polyploid cells.
Harald Genth
Rho GTPases in leukocyte adhesion and migration
Anne J. Ridley
Regulation of Rho proteins in adhesion and leukocyte transendothelial migration
Keith Burridge 

5.6. Signaling in Host-Pathogen Interactions
Chairs: Martin D. Bootman,  Patrizia Paterlini-Bréchot
The role of calcium signaling during Shigella invasion of epithelial cells
Guy Tran Van Nhieu 
Role of alfa-hemolysin induced Ca2+ signaling for the progression of uropathogenic E. coli infection within the urinary tract
Agneta  Richter-Dahlfors 
Cellular regulation of calcium; a life and death messenger
Martin D. Bootman
Patrizia Paterlini-Bréchot – title to be announced

5.7. Plasma Membrane and Cell Signaling
Chairs: Kai Simons, Hana Sychrová
Clustering of Lipid rafts.
Kai Simons
Plasma membrane signalosomes; structure-function relationships
Petr Dráber
Lateral compartments in the yeast plasma membrane: How are they formed and what are they good for?
Widmar Tanner
New lessons from the study of the dynamics and interactions of the high affinity IgE receptor
Juan Rivera 
Dynamics of Ras and Src membrane interactions in live cells and their role in signaling
Yoav I. Henis 


6.1. Mitochondrial Membranes, Apoptosis and Cancer
Chairs: Gorka Basañez , Jana Šmardová
Various modes of cell death induced by DNA damage
Boris Zhivotovsky
Mitochondrial Fission/Fusion and apoptosis 
Seamus Martin
Luca Scorrano
Model membranes as valuable tools for mechanistic studies of BCL-2 protein function
Gorka Basañez 

6.2. Virus - Cell Interactions
Chairs: Eric Hunter, Jan Svoboda
TRIM5 and Innate Immunity to HIV-1
Jeremy Luban
HIV-1 assembly and its inhibition
Hans-Georg Kräusslich
Intracellular Trafficking of Retroviral Proteins
Eric Hunter 
ERVWE1/Syncytin-1 - an extreme example of interaction between retroviruses and host cells
Francois Mallet 
The polyoma virus oncogene middle T-antigen acts as an active growth factor receptor analogue
Stephen M. Dilworth

6.3. Molecular Immunology
Chairs: Balbino Alarcon, Václav Ho?ejší
Molecular determinants of Inside-Out-Signalling in T-Lymphocytes
Burkhart Schraven 
Activation signals for naive and class-switched memory B cells
Jurgen Wienands
Fooling the antigen-presenting phagocyte: Molecular tricks and signaling of Bordetella adenylate cyclase toxin
Peter Šebo 
Role of TC21 in homeostatic antigen receptor signaling
Balbino Alarcon 

6.4. P53 New Functions, New Targets, New Controls
Chairs: A. Levine, B. Vojtesek
Single Nucleotide Polymorphisms in The p53 Pathway
Arnie Levine
Functions of mutant p53 in promoting invasion
Karen Vousden
p53-related gene signature in the process of malignant transformation – an in vitro model
Varda Rotter
Guillermina Lozano
The p53 mRNA
Robin Fåhraeus 

7.1 Nanosensors and Nanomachines
Chairs: Leonid Medved, Jan E. Dyr
Nanotechnology and Protein Arrays: Recent developments
Dolores J. Cahill 
Physiologically active nanofibrin
Leonid  Medved
Machines made from DNA
Andrew J. Turberfield
Surface plasmon biosensors and protein chips
Ji?í Homola
Nano-Devices and Next-generation DNA Sequencing Techniques
Wilhelm J. Ansorge

7.2. Photosynthesis and Solar Energy Conversion
Chairs: James Barber,  František Vácha
How Nature Solved its Energy Problem
James Barber 
Understanding the Loss Processes in Photosynthesis
Rienk Van Grondelle 
Photosystem II and water oxidation
A. W. Rutherford
Combining Biology with Technology for the Sustainable Production and Use of Fuels
Tom Moore 

7.3. Plants for the Future
Chairs: Dirk Inze, Tomáš Van?k
Improving plant cell walls for bioenergy: a systems biology approach
Wout Boerjan
Functional analysis of genes related to secondary metabolism in plants
Heiko Rischer
The potential of genetically modified plants for phytoremediation
Nelson  Marmiroli 
New Tools for the Phytoremediation of Xenobiotics
Robert  Edwards 
Plant biochemistry as a source of new anticancer drugs
Miroslav Strnad 

7.4. Biochemistry of Phytoceuticals in Plant and Mammalia
Chairs: Werner Roos, Vilím Šimánek
How plant cells survive their own toxins - controlled gene expression and dynamic compartmentation
Werner Roo
Targeting Inflammatory Pathways for Prevention and Treatment of Cancer
Bharat B. Aggarwal
Transcriptional regulation of flavonoid biosynthesis
Christian Dubos 
Transformation of Alkaloids in Plant and Mammalian Cells. Green - Red Biology
Jitka Ulrichová 

7.5. Biochemical Prospects for Better Food
Chairs: Marie-Noelle Maillard, Gary M. Smith
The main trends in biochemical research helping to improve food and feed
Jan Káš  
Genetic and Molecular Approaches to Improving the Nutritional Quality of Wheat and Other Cereals
Peter R. Shewry, C. Mils
Positive and negative effects of polyphenol oxidases in food processing
Gary M. Smith, Whitaker, J.R.
Protection of food lipids by natural antioxidants
Marie-Noelle Maillard, Cuvelier Marie-Elisabeth

7.6. Biofilms: Social Life of Microbes
Chairs: Max Dow, Jarmila Pazlarová
Biofilms and Quorum Sensing Regulation
Odille Tresse 
Biofilms, flocculation and quorum sensing in yeast: from molecular to social interactions
Kevin Verstrepen 
Cyclic di-GMP as a second messenger linking cell-cell signalling to biofilm formation in the plant pathogen Xanthomonas campestris
Max Dow
Biofilm formation of members of the genus Burkhoderia is dependent on cell-to-cell communication
Leo Eberl 

8.1. Molecular Mechanisms of Kidney Diseases
Chairs: Matthias Kretzler, Tomáš Zima
Hereditary proteinuria syndromes and mechanisms of proteinuria
Karl Tryggvason
The slit diaphragm: a signaling platform to regulate podocyte function
Thomas Benzing
Transcriptional networks in human glomerular disease: markers of podocyte function and failure
Matthias Kretzler
Oxidative stress in glomerular injury
Vladimír Tesa?
Podocytes and mesangial cells in diabetic nephropathy
Gunter  Wolf  

8.2. Proteases as Therapeutic Targets
Chairs: Nancy Thornberry, Jan Konvalinka
Comparative studies on retroviral proteases
Jozsef Tozser 
The formation of pyroGlu3-42 amyloid beta peptides - a proteolytic pathway generating the most aggressively aggregating and seeding amyloid peptides: Its discovery and treatment
Hans-Ulrich Demuth 
Dipeptidyl Peptidase IV (DPP-4) Inhibition for the Treatment of Type 2 Diabetes
Nancy Thornberry 
Conformational Change and Serpin Function
James Huntington
Protease inhibitors for the treatment of malaria
Philip Rosenthal

8.3. Biochemistry of Diabetic Complications
Chairs: Antonio Ceriello, Jan Škrha
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
Michael  Brownlee
Involvement of transcription factor nrf2 and antioxidant response element linked gene expression in countering oxidative stress in diabetes
Paul Thornalley 
Hyperglycemia, oxidative stress and diabetic complications: an overview
Antonio  Ceriello 
Beyond oxidative stress - is there a cure for vasoregression in the diabetic retina?
Hans-Peter Hammes
Drug-induced changes in biochemical indicators of diabetic vascular disease
Jan Škrha 

8.4. Cancer Stem Cells
Chairs: Stewart Sell, Milos Grim
Cancer stem cells: genetics and epigenetics
Stewart Sell
Cell death resistance in colon cancer stem cells
Jan Paul Medema 
Tumor associated fibroblasts- important players in cancer
Karel Smetana  
Cancer stem cells in radioresistance
Michael  Baumann 
Regulation of normal and leukemic human stem cells in immune deficient mice
Tsvee Lapidot 

8.5. Proteomics in Health and Diseases 
Chairs: Denis Hochstrasser, Dalibor Valík
Clinical chemistry and proteomics
Denis Hochstrasser
Proteomics of cardiovascular diseases
Jennifer Van Eyk 
Ras Nanoclustering and Intercellular Transfer: Biology, Proteomics and Exploitation for Cancer Therapy
Yoel Kloog
The application of CD antigen proteomics
Richard I. Christopherson
Proteomics of anticancer drugs
Hana Ková?ová 

W 01 Nanotherapeutics
Chairs: Karel Ulbrich
Supramolecular Nanodevices for Gene and Drug Delivery  -Challenge to Smart Nanotherapy
Kazunori Kataoka 
Polymeric Nanomedicines: Intracellular Trafficking and Subcellular Fate
Jind?ich Kope?ek 
Multifunctional nanocarriers for delivery of drugs, genes and diagnosticals in the body
Vladimír Torchilin 
Programmed polymer complexes for targeted pDNA and siRNA therapy
Ernst Wagner 
Immunotherapy of cancer with polymeric prodrugs: from dream to reality
Blanka ?íhová
Polymer Nanomaterials for CNC Drug Delivery
A.V. Kabanov