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Conference Program

Last program update - 4 June 2009

15:00 - 20:00 Registration
15:00 - 18:00
18:00 - 19:00
19:00 - 19:45
Poster mounting
Presidential address
Lessons from disorders of intracellular vitamin B12 metabolism
     B. Fowler (CH); introduction V. Kožich (CZ)
Honorary lecture
My life with SAM
     J.P. Kraus (US); introduction V. Kožich (CZ)
20:00 - 22:30 Welcome party - conference venue
8:30 - 8:45  Opening ceremony 
8:45 - 10:45 Plenary session 1 - Metabolites and their trafficking
J. Selhub (US) and W. Herrmann (DE)
8.45 - 9.15
9.15 - 9.45
9.45 - 10.15
10.15 - 10.45
J. Finkelstein (US)
M. Stipanuk (US)
P. M. Ueland (NO)
P. Stover (US)
Historical introduction on homocysteine and vitamins
Homocysteine as a good guy: Pathway to cysteine and taurine
Intracellular trafficking of folates

10:45 - 11:15
Coffee Break
11:15 - 12:45  Plenary session 2 - Genes
Chairs: H. Blom (NL) and R. Rozen (CA)
11.15 - 11.45
11.45 - 12.15
12.15 - 12.45
W. Kruger (US)
K. Blusztajn (US)
R. Zee (US)

Regulation of gene expression by methylation
Fetal programming of gene expression by nutrients
Genes regulating homocysteine and B-vitamin in metabolism in genome-wide association studies of complex disorders

12:45 - 14:00 Lunch, Poster viewing
14:00 - 15:30 Parallel sessions 1-2
  Parallel session 1 - Genetics of hyperhomocysteinemia
Chairs: H. Blom (NL) and R. Rozen (CA)
14.00 - 14.15
14.15 - 14.30
14.30 - 14.45
14.45 - 15.00
15.00 - 15.15
15.15 - 15.30
15.30 - 15.45
G. Garg (IN)
M. den Heijer (NL)
S. Sengupta (IN)
B. Wang (CN)
L. Goffinet (FR)
A. Parle-McDermott (IE)
L. Olsson (SE)

Genome wide association studies reveal novel single nucleotide polymorphisms associated with homocysteine in Indian population
Multi-locus analysis of candidate DNA variants for plasma homocysteine concentration: identification of highly associated multi-locus genotype
Genome wide DNA methylation profiling reveals epigenetic role of homocysteine in coronary artery disease patients
Methylenetetrahydrofolate reductase C677T polymorphism, hypertension, and risks of stroke: A prospective nested case-control study
Association between cleft lip and/or cleft palate and genetic and nutritional determinants of genes polymorphisms related with vitamin B12
The MTHFR677TT genotype responds less to folate deficiency compared to the 677CC genotype as assessed by global gene expression changes
Pyrosequencing assay of the UCP3 ?55C>T polymorphism: effects on plasma homocysteine in children and adolescents

  Parallel session 2 - Clinical chemistry of vitamin B12
Chairs: R. Carmel (US) and R. Green (US)
14.00 - 14.15
14.15 - 14.30
14.30 - 14.45
14.45 - 15.00
15.00 - 15.15
15.15 - 15.30
15.30 - 15.45
M.V. Bor (DK)
O. Stanger (AT)
K. Pentieva (UK)
M. Linnebank (CH)
J. Miller (US)
A. Molloy (IE)
A. Vogiatzoglou (UK)

Recommended dietary allowance for vitamin B 12. Evidence for revision based on estimated dietary intake associated with status biomarkers in healthy adult subjects
Evidence for vitamin-B12 malabsorption through short-term intake of proton pump inhibitor (PPI) esomeprazole in healthy subjects
Role of fortified foods in the maintenance of vitamin B12 status in long-term proton pump inhibitor users
On the interaction of antiepileptic drugs with folate and vitamin B12 metabolism
Biochemical severity of vitamin B12 deficiency is more pronounced in the face of elevated plasma folate in older adults
Evaluation of the diagnostic utility of holotranscobalamin for detection of vitamin B12 deficiency in older people
Plasma methylmalonic acid: determinants in a large population. Implications for assessment of vitamin B12 status

15:30 - 16:00
Coffee Break
16:00 - 17:30 Parallel sessions 3-4
  Parallel session 3 - Methylation reactions in disease
Chairs: J. Finkelstein (US) and P. Stover (US)
16.15 - 16.30
16.30 - 16.45
16.45 - 17.00
17.00 - 17.15
17.15 - 17.30
M. Lever (NZ)
C. Bossenmeyer-Pourié (FR)
R.M. Guéant-Rodriguez (FR)
G. Pourie (FR)
D. Smith (UK)

Dietary betaine methylates homocysteine and is not excreted
Hyperhomocysteinemia following prenatal methyl donor deficiency, growth retardation, and gastric ghrelin in rat offspring
Myocardial hypertrophy related with impaired synthesis of carnitine, in pups of dams deprived in methyl donors
Consequences of an early exposure to methyl donor deficiency on cerebellum-related neurobehavioral development in the rat
Determinants of essential one-carbon metabolism intermediates in cerebrospinal fluid

  Parallel session 4 - Transsulfurations and redox imbalance
Chairs: M. Stipanuk (US) and R. Banerjee (US)
16.15 - 16.30
16.30 - 16.45
16.45 - 17.00

17.00 - 17.15
17.15 - 17.30
N. Weiss (DE)
R. Austin (CA)
V. Kožich (CZ)

S. Sengupta (IN)
E.I. Chiang (TW)
Increasing intracellular thiol redox equivalents restores homocysteine-induced reduction in nitric oxide output from endothelial cells via preserving tetrahydrobiopterin bioavailability
ATF4 modulates glutathione synthesis, reactive oxygen species production and homocysteine metabolism via the transsulfuration pathway
Determination of cystathionine beta-synthase activity in plasma by LC-MS/MS - new diagnostic tool in cystathionine beta-synthase deficiency
Mitochondrial stress mediated cell death is induced by homocysteine and S-adenosyl homocysteine in Saccharomyces cereviciae
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation

17:30 - 19:30 Poster viewing with beer, wine and snacks
8:30 - 10:00 Plenary session 3 - Pathophysiology of disturbed C-1 and sulfur amino acid pool
Chairs: S. Lentz (US) and R. Austin (CA)
8.30 - 9.00
9.00 - 9.30
9.30 - 10.00
D. Jacobsen (US)
R. Banerjee (US)
K. Channon (UK)

Molecular effects of homocysteine
Sulfur amino acids and oxidative stress
Role of folates/pterines in endothelium

10:00 - 10:30 Coffee Break
10:30 - 12:30 Plenary session 4 - Short communication
Chairs: D. Jacobsen (US) and R. Austin (CA)
10.30 - 10.45
10.45 - 11.00
11.00 - 11.15
11.15 - 11.30
11.30 - 11.45
11.45 - 12.00
12.00 - 12.15
12.15 - 12.30
J. Glazier (UK)
N. Weiss (DE)
I. Blokhin (US)
D. Hubmacher (CA)
B. Shane (US)
N. Chang (KR)
R. Carmel (US)
J. Gueant (FR)

Homocysteine transport across the microvillous plasma membrane of human placenta
Homocysteine stimulates scavenger receptor CD36 expression and oxidized low-density lipoprotein uptake through peroxisome proliferator-activated receptor gamma activation in human macrophages
Dimethylarginine dimethylaminohydrolase protects from hyperhomocysteinemia-induced exacerbation of myocardial ischemia-reperfusion injury in mice
Inter-molecular disulfide-bonds are the targets for homocysteine in fibronectin, fibrillin-1 and tropoelastin: A common theme for extracellular matrix proteins?
Metabolic and genetic control of the folate-dependent methionine cycle
Effect of maternal folate status on DNA methylation and DNA methyltransferase enzymes in the cerebral cortex of the offspring
Novel public mutations define mild and severe deficiencies of transcobalamin I that cause mildly or severely low cobalamin levels
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells by upregulating PP2A, proNGF and TACE

12:30 - 14:00
Lunch, Poster viewing
14:00 - 15:45 Parallel sessions 5-6
  Parallel session 5 - Homocysteine in cancer and other diseases imbalance
Chairs: W. Kruger (US) and P. M. Ueland (NO)
14.00 - 14.15
14.15 - 14.30
14.30 - 14.45
14.45 - 15.00
15.00 - 15.15
15.15 - 15.30
15.30 - 15.45
J. Gueant (FR)
A. MacFarlane (CA)
E. Greibe (DK)
H. Powers (UK)
M. Hogeveen (NL)
O. Midttun (NO)
G. Luo (CN)

The methyl deficient diet aggravates DSS-induced colon inflammation by increasing PLA2c and COX2 expression, in the rat
Folic acid supplementation drives tumorigenesis in a model of chemically-induced colitis
STAT3 activation by folic acid may explain why excess folate promotes cancer
Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis
Maternal homocysteine and related B vitamins as risk factor for low birthweight
Vitamin B6 status and its relation to tryptophan metabolites and inflammation in patients with stable coronary artery disease
Study of aminothiols in the homocysteine metabolic pathway and diabetic nephropathy by HPLC-MS/MS

  Parallel session 6 - Neuropsychiatric disorders imbalance
Chairs: D. Smith (UK) and I. Rosenberg (US)
14.00 - 14.15
14.15 - 14.30
14.30 - 14.45
14.45 - 15.00
15.00 - 15.15
15.15 - 15.30
15.30 - 15.45

U. Lucca (IT)
C. Hughes (NI)
T.K. Nilsson (SE)
A. Fuso (IT)
T. Bottiglieri (US)

W. Herrmann (DE)
C. Noll (FR)
Hyperhomocysteinemia as a risk factor for dementia: The Canton Ticino Prospective Study
B vitamin status and cognitive decline in healthy older adults in a 4 year follow-up study
Csf/Serum folate gradient: Physiology and determinants with special reference to dementia
Effect of one-carbon metabolism alteration on DNA methylation machinery in Alzheimer?s Disease models
L-dopa induces changes in methylation metabolites, PP2A demethylation and hyper-phosphorylation of Tau protein in mouse brain
Methylation and neurodegeneration: The role of hyperhomocysteinemia and B-vitamin deficiency in neurogenerative diseases
Overexpression of Dyrk1a, a serine/threonine kinase, in brain of hyperhomocysteinemic mice

15:45 - 16:15
Coffee Break
16:15 - 18:00 Parallel session 7-8
  Parallel session 7 - Clinical chemistry of homocysteine and related compounds
Chairs: W. Herrmann (DE) and H. Refsum (UK, NO)
16.15 - 16.30
16.30 - 16.45
16.45 - 17.00
17.00 - 17.15
17.15 - 17.30
17.30 - 17.45
17.45 - 18.00

L. Husemoen (DK)
T. Tamura (US)
A. Ulvik (NO)
R. Delport (ZA)
S. Slow (NZ)
R. Diaz Arrastia (US)
S. Bailey (US) 

Changes in lifestyle and total homocysteine: a five year follow-up study.
Relationship between body-mass index and blood folate and total homocysteine concentrations in Japanese adults
Short and long-term effects of tobacco smoking on circulating concentrations of the vitamins folate, B6, B12, and riboflavin
Endocrine-disrupting effects of DDT in relation to homocysteine metabolism
Does abnormal urinary betaine loss explain the increase in plasma homocysteine following fibrate therapy?
Effect of high and low dose B vitamin supplementation on plasma S-adenosylmethionine, S-adenosylhomocysteine and asymmetric dimethylarginine in elderly subjects
Differential alteration of plasma thiols and S-adenosylmethionine upon treatment with high dose folic acid or 5-methyltetrahydrofolate

  Parallel session 8 - Inborn errors of metabolism and varia
Chairs: G. Andria (IT) and B. Fowler (CH)
16.15 - 16.30
16.30 - 16.45

16.45 - 17.00
17.00 - 17.15
17.15 - 17.30
17.30 - 17.45
17.45 - 18.00

S. Stabler (US)
W. Kruger (US)

V. Kozich (CZ)
H. Jakubowski (US)
Z.S. Zhou (US)
P. Stover (US)
G. Hay (NO)

Potential misdiagnosis of hyperhomocysteinemia due to cystathionine beta-synthase deficiency during pregnancy
Restoration of function to missense mutant cystathionine beta-synthase by treatment with proteasome inhibitors
Changing phenotype presentation in Czech patients with homocystinuria
Homocysteine-thiolactonase activity of paraoxonase 1 (PON1) protects proteins against N-homocysteinylation in humans
Homocysteine thiolactone-mediated protein modification and crosslinking
Shmt1 and the metabolic origin of folate-responsive neural tube defects
Predictors of folate and cobalamin status at birth and in breastfed infants at 6 mo of age

  Free evening
8:30 - 9:00 Sulfur compound of the year
  C. Szabo (US) Hydrogen sulfide: Its origin and cellular effects
9:00 - 10:30 Plenary session 5 - Short communications - Epidemiological studies
Chairs: R. Clarke (UK) and M. Cattaneo (IT)
9.00 - 9.15
9.15 - 9.30
9.30 - 9.45
9.45 - 10.00
10.00 - 10.15
10.15 - 10.30

A. Towfighi (US)
B. Wang (CN)
E.R. Pedersen (NO)
D. Bennett (UK)
C. Pfeiffer (US)
H. Schartum-Hansen (NO)

The combination of hypertension and elevated serum homocysteine is associated with greater stroke occurrence
H-type hypertension and risk of stroke: A prospective, nested case-control study
Homocysteine, markers of immune activation and long-term prognosis in patients with stable angina pectoris
Evidence against a causal association of homocysteine and coronary heart disease A Mendelian randomisation study
Relationship of plasma vitamin B12, methylmalonic acid, and homocysteine levels in the United States, 1999-2004
Betaine excretion in urine is associated with components of the metabolic syndrome and microalbuminuria

10:30 - 11:00 Coffee Break
11:00 - 12:15 Plenary session 6 - Short communications - Vitamin treatment
Chairs: D. Smith (UK) and M. Morris (US)
11.00 - 11.15
11.15 - 11.30
11.30 - 11.45
11.45 - 12.00
12.00 - 12.15

J. Miller (US)
E. Nexo (DK)
J. Dierkes (DE)
M. Ebbing (NO)
R. Green (US)

Physiological doses of cyanocobalamin are modified or degraded in the gastrointestinal tract: implications for vitamin B12 bioavailability and fortification
Most patients on vitamin B12 injection therapy doesn't need this treatment since they can absorb small doses of oral B12
B-Vitamins and total mortality and cardiovascular disease in patients with end-stage renal disease. A randomized clinical trial
Cancer incidence, cancer mortality and all-cause mortality after treatment with folic acid and vitamin B12 in ischemic heart disease patients
Breast cancer incidence: a possible relationship to folic acid fortification?

12:15 - 13:15
Lunch, Poster viewing
13:15 - 15:15 Summary from parallel sessions

20:00 - 24:00 Conference dinner - Žofín Palace
9:00 - 10:30 Plenary session 7 - Lessons from intervention trials and folate fortification I
Chairs: I. Rosenberg (US) and A. Molloy (IE)
9.00 - 9.30
9.30 - 10.00
10.00 - 10.30

M. Morris (UK)
G. Shaw (US)
D. Smith (UK)

Interplay between folates and vitmain B12 in human populations
Diseases of the fetal development
Congnitive function in older age

10:30 - 11:00 Coffee Break
11:00 - 12:00 Plenary session 8 - Lessons from intervention trials and folate fortification II
Chairs: W. Herrmann (DE) and M. Cattaneo (IT)
11.00 - 11.30
11.30 - 12.00

R. Clarke (UK)
S. E. Vollset (NO)

Cardiovascular diseases
12:00 - 13:00 Discussion and vote on mandatory folate/B12 fortification
Panelists I. Rosenberg (US), H. Refsum (UK, NO), R. Green (US), R. Carmel (US)
13:00 Conference close